Novel dual GIP and GLP-1 receptor agonist Tirzepatide showed promising results for both reduction in A1C and weight loss. The pharmaceutical company Eli Lilly recently released the preliminary results of their novel investigational drug, Tirzepatide. Tirzepatide is a dual, Glucose-dependent insulinotropic polypeptide (GIP) and a Glucagon-like peptide-1 receptor agonist (GLP-1 RA). The mechanisms of mimicking the functions of incretin hormones represent a new class of medication to treat type 2 diabetes. GLP-1 RA is considered second-line therapy for patients with type 2 diabetes and has some advantages over other drug classes, including administering a medication less frequently and the benefit of losing weight. Tirzepatide is administered subcutaneously once a week as are other GLP-1 RA. Eli Lilly conducted some randomized clinical trials where they evaluated the safety and efficacy of Tirzepatide in patients with type 2 diabetes. In SURPASS-3, they compared Tirzepatide with Degludec in patients with type 2 diabetes in 122 sites. The trial was a randomized clinical phase 3, open-label and parallel assignment trial. In the study, 1,444 participants were randomized in a 1:1:1 ratio using Tirzepatide in 5mg, 10mg, and 15mg, or degludec. The primary intervention was reducing HbA1C at week 52 compared to baseline while using Tirzepatide 10 mg and 15 mg. The secondary outcomes looked for changes in body weight from baseline at week 52, changes in fasting serum glucose, percentages of participants achieving an HbA1C 5% of weight loss, and hypoglycemic episodes. Participants were all adults with type 2 diabetes with HbA1C reported as ≥7% and ≤10% at baseline and BMI ≥25kg/m2.

Science continues to prove that the old adage "you are what you eat" is profoundly true. This is because you have trillions of microorganisms living in your gut, which are directly responsible for nearly every aspect of your health. These microbes make up what’s called your "gut microbiota." They are especially influential in determining your likelihood of gaining excessive weight, becoming obese, and developing obesity-related diseases like diabetes, Medic GLP heart disease, and premature death. The gut microbiome (the expressed genes of your gut microbiota) plays a major role in your metabolism through energy production, storage, and expenditure. So, it’s no surprise that science has found a strong connection between gut microbiome imbalance and metabolic syndrome. Yikes! If you have the wrong mix of microbes, it could be making it tough for you to get your health on track! Did you know: Scientists can actually look at your gut microbiome composition and tell with 90% accuracy if you are obese or lean. That’s pretty impressive, isn’t it?

1. Unable to lose weight and keep it off? 2. Struggling to fight cravings? 3. Sick of starving yourself for MedicGLP weight management loss? 4. Baffled as to why no diet seems to really work for you? Depending on the composition of your gut microbiome, your microbes can either boost your health or weigh you down (figuratively and literally). The good news is this: You have control over these little guys with every bite you eat. Diet has the power to change the landscape of your gut microbiome. So, if you’ve tried multiple diets and can’t seem to get the results you want, it’s time to look into your gut microbiome.Will You Lose Weight Naturally on an Individualized Diet? If you’ve been struggling to lose weight and keep it off - it could be your gut microbiome. While Viome doesn’t guarantee weight loss, it has been an exciting result many of our customers have reported. "Fiona’s update day 37!

We know weight loss can be tough. Find out if your weight struggles are due to a gut microbiome imbalance with Viome - and let’s tip the scales in your favor. Your gut microbes actually digest much of your food for you. When your gut microbiota help digest your food, they turn it into nutrients, neurotransmitters, vitamins, hormones, and more. Through these metabolites, the composition of your gut microbiome influences nearly every metabolic activity. It’s accurate to think of your gut microbiome as an organ that’s part immune system and part energy regulator. If your gut microbiome is imbalanced, certain bacteria end up working to protect themselves from the harsh environment and are not able to help you. In the worst case scenario, you can have microbiota adding to your health problems, making it harder for you to get healthy and lose weight. Viome’s metatranscriptomic technology has allowed us identify microbial pathways and functions, specifically those that influence weight loss or gain.